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Dapoxetine 30mg dosage. There was an absence of significant difference found between those groups, which may be due to the large sample size (n = 90) of the current study. Given that there were no significant differences in mean age and gender between the three groups, as well same baseline scores of the different groups between three groups, we suggest that the results obtained in current study may be generalized to other young male patients who present with an atypical pattern of depression. The study was based on a convenience sample of patients referred to our tertiary psychiatric centre by two psychiatrists. It is of interest to note that the mean age of participants was 23.4, and 23.6 years, respectively, which is comparable to the age of majority patients attending our centre. The lack of a gender difference in mean age and gender could have resulted from the large numbers of male participants in the different groups. However, a gender difference in the pattern of depressive symptoms was not found between the participants in three treatment groups. Furthermore, we could not discern any significant differences in mood or quality of life, overall functional capacity as determined by the General Health Questionnaire-11, Beck Depression Inventory or the Social Responsiveness Inventory, at endpoint of the study. In conclusion, patients who were treated with aripiprazole compared to placebo showed better outcomes in their scores on the HAM-D as well in score on the Young Mania Rating Scale. However, the significant difference between atypical and typical depressive symptoms was not observed until 2 weeks after treatment and then went away completely at 12 weeks. Patients treated with atypical antipsychotics showed better outcomes on the HAM-D at 2, 6 and 12 weeks, respectively, but again remained significantly depressed compared to the placebo group at 2 weeks. Therefore, it remains to be determined whether the significant improvement in HAM-D and the Young Mania Rating Scale with atypical antipsychotics could be explained by a potential improvement in depression. Although a large number of patients were treated with atypical antipsychotics in a research study, there is no evidence of a clinically significant difference between the two groups. Patients having higher symptoms of depression should therefore be considered differently from those who have a mild depressive episode, and this can be achieved by a combination of psychosocial and pharmacological interventions. Acknowledgments This work was supported by Janssen Pharmaceuticals Inc. References 1. Kompf HV, Stoffelen A, Rätz U. Atypical antipsychotics and their combination for the Treatment of Depression and Anxiety: a systematic review. Clin Psychiatry 1992; 19 : 51 - 57. 2. discount drug store online shopping Dennison BA, Seaman DA, Biesecker et al. Comparison of the clinical efficacy olanzapine mesylate hydrochloride and risperidone in treatment of patients with severe major depressive disorder. Arch Gen Psychiatry 1991; 50 : 991 - 97. 3. Kompf Buy flagyl online ireland HV, Heppner R, Biesecker BA, et al. Comparison of the efficacy olanzapine and risperidone in the prevention of relapse major depressive disorder. A randomized double-blind clinical trial. Arch Gen Psychiatry 1992; 51 : 755 - 62. 4. Heppner R, Schottler M, Kompf HV, et al. Psychotherapy in major depression: a randomized trial. Arch Gen Psychiatry 1993; 53 : 577 - 82. 5. Kompf HV, Heppner R, Biesecker BA, et al. Comparison of the efficacy olanzapine mesylate hydrochloride and risperidone in the prevention of relapse major depressive disorder. A randomized double-blind clinical trial. Arch Gen Psychiatry 1993; 53 : 543 - 9. 6. Stutz SM, Schottler M, Griesinger P, et al. Psychotherapy versus drugs for major depression. A randomized clinical trial.. Arch Gen Psychiatry 1995; 54 : 439 - 47. 7. Altenmüller S, Meinhardt A, Stenkovic K, et al. Long-term outcome of first-episode patients treated with atypical antipsychotic drugs versus conventional antipsychotics. Am J Psychiatry 1995; 152 : 955 - 62. 8. Stutz SM, Heppner R, Biesecker BA, et al. Comparison of the efficacy olanzapine and risperidone in the prevention of relapse people with schizophrenia. A randomized double-blind clinical trial. Arch Gen Psychiatry 1996; 55 : 863 - 71. 9. Kompf HV, Heppner R, Biesecker BA, et al. Comparison of the efficacy olanzapine and risperidone in the prevention of relapse those with bipolar depression.