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Plasil drug dosage -increasing treatment regimen, which includes cyclosporine A and B their respective salts. Drugs in the group include, but are not limited to cyclosporine A, B, cyclophosphamide, hydazone, polymyxin and/or verapamil. Each of the drugs can be administered in vivo and/or ex to increase the levels of an immune response and/or anti-inflammation response, and thereby improve functional and/or structural outcomes. The present invention is directed to a method of inhibiting NF-κB signaling in the brain, comprising administering an effective amount of a therapeutically compound the present invention for each therapeutic or prophylactic purpose. In some embodiments, the therapeutically effective amount of a compound the present invention is in a concentration range from about 0.01, 1.0, 20.0, 100.0, 1000.0 and/or about 10000.0 fold above below the maximal detectable concentration. In some embodiments, the therapeutically effective amount of a compound the present invention is in a concentration range from about 0.001 and 100.0-fold above the maximal detectable concentration. In some embodiments, the therapeutically effective amount of a compound the present invention is in a concentration range from about 0.0001 and 10.0-fold above the maximal detectable concentration. In some embodiments, the therapeutic or prophylactic compound of the present invention is cyclosporine. In some embodiments, the therapeutically effective amount of a compound the present invention is least effective amount of cyclosporine. In some embodiments, the therapeutically effective amount of a compound the present invention is for use in a treatment of subject and is administered to/for treatment in the brain vivo or ex vivo. The term "anti-inflammatory agent" of present invention includes, but is not limited to, the substances discussed above and combinations of such substances. Also included in this range of anti-inflammatory agents are cytokines, pro-inflammatory cytokine activators and antagonists, as discussed above. The range of anti-inflammatory agents is not limited to the above substances as used herein. The present invention also extends to anti-inflammatory compounds that are not listed. The term "non-steroidal anti-inflammatory agent" of the present invention also includes.

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